Video-on-Demand Library


Collection
Keyword or phrase

Topic

05 May 2026

This talk will explore the “replication crisis” in science, focusing on how testing large numbers of hypotheses can lead to false positive findings. It introduces key statistical approaches—False Discovery Rate (FDR) and shrinkage methods—to address this issue, and explains their conceptual foundations and connections. The session will also highlight how these tools can be understood within an empirical-Bayesian framework, linking significance testing with effect size estimation.

Read more...

Science is currently facing a ‘replication crisis’ – a concern that many scientific findings reported are difficult or impossible to reproduce.   A major cause of this is the availability of technology that permits the exploration and testing of very large numbers of hypotheses, some of which will almost certainly show significant or large effects by chance, even when no real effects are present: this is the ‘multiplicity’ or ‘multiple testing’ problem.   The statistical tools available to address this problem include: the False Discovery Rate (FDR), which is specified in relation to the subset of the m hypotheses tested for which the discovery of an effect is reported, and which indicates the proportion of these ‘discoveries’ that is expected to be false; and shrunk estimates, which reduce the estimated effect, in relation to every individual hypothesis, from the observed value towards the null value. This talk will first examine the conceptual basis for each of these tools, then consider how they are connected.   Though the FDR and shrunk estimates are both conventionally presented in the frequentist statistical framework, they can both also be presented in empirical-Bayesian terms, the prior probability distribution being calculated from the data relating to the m hypotheses tested, as follows: in the case of the FDR, from the proportion of the m significance tests conducted that give a p-value at or below the specified significance threshold, and that are therefore announced as ‘discoveries’; and in the case of shrunk estimates, from the distribution of the observed effect sizes over the m hypotheses. Based on this connection, a formal relationship between FDR values and shrunk estimates will be presented, and it will be argued that these two tools can profitably be used in conjunction.   Their combined application, both to real (human gene expression) data and to simulated data, will be illustrated.

21 April 2026

Webinar targeting clinical researchers, medical writers, statisticians and professionals involved in reporting clinical trials results who would like to enhance clinical study reporting using the estimand framework. Key takeaways: - Why estimands matter for decision-making and effective communication - Practical considerations for integrating estimands into study reports and registries 00:00 - Introduction to the Estimands Academy for Trial teams and this webinar 01:24 - The presenters and panelists 03:43 - Publication: Realizing the benefits of the estimand framework when reporting and communicating clinical trial results – some recommendations 05:17 - Describing and Reporting Treatment Effects of Interest 16:34 - Treatment Effects in Study Reports and Submission Documents 30:46 - Estimands in Public Clinical Trial Registries 41:05 - Closing remarks 42:35 Q&A

Read more...

00:00 - Introduction to the Estimands Academy for Trial teams and this webinar
01:24 - The presenters and panelists
03:43 - Publication: Realizing the benefits of the estimand framework when reporting and communicating clinical trial results – some recommendations
05:17 - Describing and Reporting Treatment Effects of Interest
16:34 - Treatment Effects in Study Reports and Submission Documents
30:46 - Estimands in Public Clinical Trial Registries
41:05 - Closing remarks
42:35 Q&A

In this webinar we explore practical strategies for applying the estimand framework in clinical study reporting. Drawing on real-world experiences and case studies, we will share recommendations to 
•       Understand the role of estimands in improving transparency and interpretation of trial results. 
•        Navigate common challenges in implementing the framework during reporting. 
•        Apply best practices to enhance regulatory submissions, webposting in public registries (clinicaltrials.gov/CTIS), and scientific publications. 
The webinar targets drug developers involved in clinical trial design, data analysis, or regulatory submissions, who are interested in realizing the full potential of the estimand framework

 

Publication: Lanius V, Glocker B, Lösch C, Bratton DJ, Callegari F, Wright M, Rajamäki S. Realizing the benefits of the estimand framework when reporting and communicating clinical trial results-some recommendations. Trials. 2025 Jul 11;26(1):241. doi: 10.1186/s13063-025-08915-6. PMID: 40640873; PMCID: PMC12247363.

08 April 2026

The recently published study Make Better Choices 2 evaluates the effect of activity and stress management on our life. Steve Mallett guides the way through different choices to visualise the actual study results. All plots are available on the Wonderful Wednesday blog.

Read more...

Starting with the very basic plot given in the publication several improvements in readability were performed. One goal is to avoid cognitive burden to the reader for clear and effective visual communication. The new challenge is on recently published results of a glycemic control study with an interesting conclusion. See the Wonderful Wednesday homepage for more detail. 

Wonderful Wednesdays are brought to you by the Visualisation SIG. The Wonderful Wednesday team includes Bodo Kirsch, Steve Mallett, Rhys Warham, Lovemore Gakava, Zara Sari, Zachary Skrivanek, Lorenz Uhlmann, Paolo Eusebi

24 March 2026

Join our Health Technology Assessment (HTA) European Special Interest Group (ESIG) for a webinar on the strategic role of statisticians in the Joint Clinical Assessment (JCA). The introduction of the JCA marks a new era for evidence generation and market access in Europe. As HTA requirements become more harmonized and methodologically demanding, the role of statisticians has evolved far beyond data analysis. Today, statistical expertise is central to shaping clinical development strategies, designing robust comparative evidence, and ensuring that submissions withstand the scrutiny of EU-level assessors. In this webinar, we explore how statisticians contribute strategically to successful JCA outcomes.

Read more...

11 March 2026

Comparing five different treatments regarding five different domains is not an easy task to do. Rhys Warham is presenting ways of solving this challenge visually. All plots are available on the Wonderful Wednesday blog.

Read more...

There are various ways to deal with multidimensional comparisons on a two-dimensional display. See the pros and cons of radar charts, heat maps, trade-off plots and contour maps. The next challenge is on recently published results of the Make better choices 2 trial. See the Wonderful Wednesday homepage for more detail.

Wonderful Wednesdays are brought to you by the Visualisation SIG. The Wonderful Wednesday team includes Bodo Kirsch, Steve Mallett, Rhys Warham, Lovemore Gakava, Zara Sari, Zachary Skrivanek, Lorenz Uhlmann, Paolo Eusebi

04 March 2026

This webinar brings together three complementary perspectives to help PSI contributors develop conference presentations and posters that communicate clearly, engage audiences, and reflect inclusive practice. Across the session, participants will explore how to refine their message, prepare effectively, and deliver with confidence.

Read more...

Claire Brittain, Emma Crawford, Karen Smith, Tim Morris

We begin by examining how to move from substance to message, focusing on what makes a talk genuinely resonate. This segment encourages presenters to think about what their audience will remember, how to frame complex ideas with clarity, and how to avoid common communication pitfalls that can dilute an otherwise strong contribution. The aim is to help presenters shape their material in a way that supports understanding and impact.

The second session turns to the practicalities of preparation. Rather than offering an exhaustive checklist, it highlights the habits and decisions that make the biggest difference: identifying core messages, preparing materials with intention, rehearsing in ways that improve delivery, and navigating the realities of both oral and poster formats. The emphasis is on preparation that supports accessibility, reduces stress, and helps presenters feel ready for the day.

We close with a reflective session on inclusive presenting, inviting participants to consider their own experiences as audience members and presenters. Through guided questions and shared insights, the session surfaces the barriers people commonly face in talks and explores simple, memorable principles that help make presentations more inclusive.

Together, these sessions equip attendees to design, prepare, and deliver conference contributions that are engaging, inclusive, and impactful.

10 February 2026

There was a publication in 2025 about a successful study without any graphical presentation of the results. Bodo Kirsch and Rhys Warham are presenting effective visualisations, that could have been used. Also available on the Wonderful Wednesday blog.​

Read more...

Visualisations can convey a message much faster than a table. An icon array makes the difference between the treatment arms viscerally tangible. One forest plot can summarize information of multiple tables and help seeing consistence at on glance. The distribution plot helps to understand the underlying data in a detail that would be unreasonable to give in writing or even as a table. For the clinical context a simple plot shows absolute risk differences and NNT. The next challenge is on treatment attributes. See the Wonderful Wednesday homepage for more detail.  

Wonderful Wednesdays are brought to you by the Visualisation SIG. The Wonderful Wednesday team includes Bodo Kirsch, Zachary Skrivanek, Lorenz Uhlmann, Steve Mallett, Rhys Warham, Paolo Eusebi, Lovemore Gakava  

03 February 2026

Read more...

In this presentation, we evaluate both Type I error rates and powers of the 13 tests investigated in Pham et al. (2020) spanning ANOVA-based tests, structured means modeling (SMM), and mixed-effects models—under diverse conditions, including (un)equal variances, (non-)normal distributions, and (un)balanced designs. Two additional mixed-effects models (homogeneous-variance mixed-effects model and adaptive mixed-effects model) are introduced and assessed alongside the 13 tests. We also consider the Kenward-Roger approximation of degrees of freedom for the 3 mixed-effects models, which generally offers more reliable type I error rate than the Satterthwaite approximation. Some recommendations about analysis for data from single-factor experiments will finally be given.

14 January 2026

This is a follow-up on the challenge from September 2025. Rhys Warham presents a newly developed data explorer. Also available on the Wonderful Wednesday blog.

Read more...

Efficient data exploration is crucial to understand the treatment and the population. The presented data explorer allows a detailed look into the data while adjusting variables, filters and thresholds. The next challenge is to fill the visual gap in a recent publication on exercise during pregnancy. See the Wonderful Wednesday homepage for more detail.

Wonderful Wednesdays are brought to you by the Visualisation SIG. The Wonderful Wednesday team includes Bodo Kirsch, Zachary Skrivanek, Lorenz Uhlmann, Steve Mallett, Rhys Warham, Paolo Eusebi, Lovemore Gakava

10 December 2025

The last webinar in 2025 is a funny way to look at the gestalt principals. Steve Mallett guides the way to an effective visualisation. Also available on the Wonderful Wednesday blog.

Read more...

Winter is coming. A good visualisation can lighten up the mood or give valuable insight. Interactive plots invite to explore data. And AI can support the coding to safe time. Learn more in this webinar. The next challenge is one more time on fatty liver disease. See the Wonderful Wednesday homepage for more detail.

Wonderful Wednesdays are brought to you by the Visualisation SIG. The Wonderful Wednesday team includes Bodo Kirsch, Zachary Skrivanek, Lorenz Uhlmann, Steve Mallett, Rhys Warham, Mark Baillie, Paolo Eusebi, Martin Brown, Benjamin Lang, Lovemore Gakava, Aditeya Pandey

18 November 2025

Join our webinar to learn how algorithmic allocation—like genetic algorithms and simulated annealing—creates better-balanced treatment groups than simple randomization, especially in small clinical and in vivo studies. We'll explain the theory, show performance comparisons with random and exhaustive methods, and discuss practical extensions and computational benefits.

Read more...

Randomizing subjects into treatment groups reduces confounding in clinical and preclinical studies, but simple complete randomization can fail in small trials (especially in vivo) where group imbalances are more likely. More structured methods (e.g., randomized block designs) help, but algorithmic allocation gives the best balance. One effective algorithmic approach uses a genetic-algorithm framework inspired by evolutionary theory: it searches for partitions of the dataset that minimize a predefined fitness function measuring imbalance. Compared with simple random allocation and exhaustive search, this genetic algorithm produced more homogeneous experimental groups, ran far faster than exhaustive search, and its computational advantage grows quickly with more subjects and more design factors. Extensions and related approaches (for example, simulated annealing) can further adapt or improve the method.

13 November 2025

Cesar Torres (FDA) and Suzie Cro (Imperial College London) present their recent work on tipping point analysis and missing data. The webinar was chaired by Kevin Ding,

Read more...

Page:

Upcoming Events

Latest Jobs